InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNA4

Summary

InnateDB Protein

IDBP-103091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA4

Protein Name

ephrin-A4

Synonyms

EFL4; EPLG4; LERK4;

Species

Homo sapiens

Ensembl Protein

ENSP00000357394

InnateDB Gene

IDBG-409441 (EFNA4)

Protein Structure

UniProt Annotation

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Subcellular Localization

Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0030316	osteoclast differentiation
GO:0046849	bone remodeling
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane