Version 5.4
Homo sapiens Gene: EFNA4
Summary
InnateDB Gene IDBG-409441.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNA4
Gene Name ephrin-A4
Synonyms EFL4; EPLG4; LERK4
Species Homo sapiens
Ensembl Gene ENSG00000243364
Encoded Proteins
IDBP-103091
ephrin-A4
IDBP-103093
ephrin-A4
IDBP-388815
ephrin-A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155063731-155069553
Strand Forward strand
Band q21.3
Transcripts
ENST00000368409 ENSP00000357394
ENST00000359751 ENSP00000352789
ENST00000427683 ENSP00000414378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0030316 osteoclast differentiation
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028040
View Gene Order
ENSBTAG00000010673
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt P52798
TrEMBL
UniProt Splice Variant
Entrez Gene 1945
UniGene Hs.449913
RefSeq NM_005227 NM_182689 NM_182690
HUGO HGNC:3224
OMIM 601380
CCDS CCDS1089 CCDS41407 CCDS44237
HPRD 03224
IMGT
EMBL AJ006352 AJ006353 AL691442 BC107483 CH471121 CR533569 U14188
GenPept AAC50079 AAI07484 CAA06992 CAA06993 CAG38600 EAW53138 EAW53139
RNA Seq Atlas 1945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca