InnateDB Protein
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IDBP-103093.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EFNA4
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Protein Name
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ephrin-A4
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Synonyms
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EFL4; EPLG4; LERK4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352789
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InnateDB Gene
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IDBG-409441 (EFNA4)
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Protein Structure
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Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
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Subcellular Localization |
Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 2: Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001799
Ephrin
IPR008972
Cupredoxin
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PFAM |
PF00812
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PRINTS |
PR01347
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P52798
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PhosphoSite |
PhosphoSite-P52798
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1945
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UniGene |
Hs.449913
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RefSeq |
NP_872632
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HUGO |
HGNC:3224
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OMIM |
601380
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CCDS |
CCDS41407
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HPRD |
03224
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IMGT |
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EMBL |
AJ006352
AJ006353
AL691442
BC107483
CH471121
CR533569
U14188
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GenPept |
AAC50079
AAI07484
CAA06992
CAA06993
CAG38600
EAW53138
EAW53139
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