Version 5.4
Homo sapiens Protein: RXFP4
Summary
InnateDB Protein IDBP-103335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RXFP4
Protein Name relaxin/insulin-like family peptide receptor 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357301
InnateDB Gene IDBG-103333 (RXFP4)
Protein Structure
UniProt Annotation
Function High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. {ECO:0000269PubMed:14522967, ECO:0000269PubMed:15525639}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon. {ECO:0000269PubMed:14530218}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038166 angiotensin-activated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00241
PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDU9
PhosphoSite PhosphoSite-Q8TDU9
TrEMBL
UniProt Splice Variant
Entrez Gene 339403
UniGene Hs.449914
RefSeq NP_871001
HUGO HGNC:14666
OMIM 609043
CCDS CCDS1124
HPRD 16421
IMGT
EMBL AB065617 AB083593 AL355388 AY170824 AY288415 AY394502 BC101507 BC101509 EU432129
GenPept AAI01508 AAI01510 AAO17676 AAP72124 AAQ92316 ABY87928 BAB89306 BAC05844 CAH72626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca