Version 5.4
Homo sapiens Protein: SSR2
Summary
InnateDB Protein IDBP-103353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSR2
Protein Name signal sequence receptor, beta (translocon-associated protein beta)
Synonyms TLAP; TRAP-BETA; TRAPB;
Species Homo sapiens
Ensembl Protein ENSP00000295702
InnateDB Gene IDBG-103349 (SSR2)
Protein Structure
UniProt Annotation
Function TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006412 translation
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008856 Translocon-associated protein subunit beta
PFAM PF05753
PRINTS
PIRSF PIRSF016400
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43308
PhosphoSite PhosphoSite-P43308
TrEMBL E9PQI4
UniProt Splice Variant
Entrez Gene 6746
UniGene
RefSeq NP_003136
HUGO HGNC:11324
OMIM 600867
CCDS CCDS1126
HPRD 02923
IMGT
EMBL AK222600 AK300678 AK313821 AL355388 AY251536 BC000341 CH471121 CR456973 D37991 X74104
GenPept AAH00341 AAP20059 BAA07206 BAD96320 BAG36556 BAG62361 CAA52207 CAG33254 CAH72631 CAH72632 EAW53010 EAW53011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca