InnateDB Protein
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IDBP-103369.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LAMTOR2
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Protein Name
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late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357287
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InnateDB Gene
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IDBG-103365 (LAMTOR2)
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Protein Structure
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Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269PubMed:20381137, ECO:0000269PubMed:22980980}.
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Subcellular Localization |
Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
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Disease Associations |
Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP) [MIM:610798]: This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. {ECO:0000269PubMed:17195838}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004942
Dynein light chain-related
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PFAM |
PF03259
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PRINTS |
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PIRSF |
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SMART |
SM00960
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2Q5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
28956
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UniGene |
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RefSeq |
NP_001138736
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HUGO |
HGNC:29796
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OMIM |
610389
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CCDS |
CCDS44243
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HPRD |
17463
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IMGT |
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EMBL |
AF070659
AK307086
AL355388
BC024190
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GenPept |
AAD20965
AAH24190
CAH72635
CAH72636
CAH72637
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