InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMTOR2

Summary

InnateDB Protein

IDBP-103371.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMTOR2

Protein Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357285

InnateDB Gene

IDBG-103365 (LAMTOR2)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269PubMed:20381137, ECO:0000269PubMed:22980980}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP) [MIM:610798]: This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. {ECO:0000269PubMed:17195838}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0016049	cell growth
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0043547	positive regulation of GTPase activity
GO:0071230	cellular response to amino acid stimulus