Version 5.4
Homo sapiens Protein: PMF1
Summary
InnateDB Protein IDBP-103421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMF1
Protein Name polyamine-modulated factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357260
InnateDB Gene IDBG-103415 (PMF1)
Protein Structure
UniProt Annotation
Function Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000269PubMed:10419538, ECO:0000269PubMed:11256947, ECO:0000269PubMed:15502821, ECO:0000269PubMed:16585270}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:16585270}. Note=Associated with the kinetochore.
Disease Associations
Tissue Specificity Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver. {ECO:0000269PubMed:10419538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007128 Nnf1
PFAM PF03980
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1K2
PhosphoSite PhosphoSite-Q6P1K2
TrEMBL D3DVB3
UniProt Splice Variant
Entrez Gene 11243
UniGene
RefSeq NP_009152
HUGO HGNC:9112
OMIM 609176
CCDS CCDS30886
HPRD 11441
IMGT
EMBL AF141308 AF141309 AF141310 AK124646 AK289490 AK290260 AL080101 AL135927 BC033656 BC050735 BC056417 BC065031 CH471121
GenPept AAD50080 AAD50081 AAH50735 AAH56417 AAH65031 BAC85916 BAF82179 BAF82949 CAH10730 CAI15535 CAI15536 CAI15538 CAI15539 CAI15540 EAW52987 EAW52988 EAW52989 EAW52990

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca