InnateDB Protein
|
IDBP-103427.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PMF1
|
Protein Name
|
polyamine-modulated factor 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000357256
|
InnateDB Gene
|
IDBG-103415 (PMF1)
|
Protein Structure
|
|
Function |
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. {ECO:0000269PubMed:10419538, ECO:0000269PubMed:11256947, ECO:0000269PubMed:15502821, ECO:0000269PubMed:16585270}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:16585270}. Note=Associated with the kinetochore.
|
Disease Associations |
|
Tissue Specificity |
Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver. {ECO:0000269PubMed:10419538}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
22
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007128
Nnf1
|
PFAM |
PF03980
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6P1K2
|
PhosphoSite |
PhosphoSite-Q6P1K2
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
11243
|
UniGene |
|
RefSeq |
NP_001186583
|
HUGO |
HGNC:9112
|
OMIM |
609176
|
CCDS |
CCDS55648
|
HPRD |
11441
|
IMGT |
|
EMBL |
AF141308
AF141309
AF141310
AK124646
AK289490
AK290260
AL080101
AL135927
BC033656
BC050735
BC056417
BC065031
CH471121
|
GenPept |
AAD50080
AAD50081
AAH50735
AAH56417
AAH65031
BAC85916
BAF82179
BAF82949
CAH10730
CAI15535
CAI15536
CAI15538
CAI15539
CAI15540
EAW52989
EAW52990
|
|
|