InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IQGAP3

Summary

InnateDB Protein

IDBP-103538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP3

Protein Name

IQ motif containing GTPase activating protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354451

InnateDB Gene

IDBG-103532 (IQGAP3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0017016	Ras GTPase binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000187	activation of MAPK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0008361	regulation of cell size
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0032320	positive regulation of Ras GTPase activity
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0070371	ERK1 and ERK2 cascade
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0016328	lateral plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000593 RasGAP protein, C-terminal
IPR001202 WW domain
IPR001715 Calponin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF03836
PF00397
PF00307
PF00616

PRINTS

PIRSF

SMART

SM00015
SM00456
SM00033
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86VI3