Version 5.4
Homo sapiens Gene: IQGAP3
Summary
InnateDB Gene IDBG-103532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQGAP3
Gene Name IQ motif containing GTPase activating protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183856
Encoded Proteins
IDBP-103538
IQ motif containing GTPase activating protein 3
IDBP-592924
IQ motif containing GTPase activating protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156525405-156572604
Strand Reverse strand
Band q22
Transcripts
ENST00000361170 ENSP00000354451
ENST00000491900 ENSP00000436603
ENST00000476565
ENST00000498755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0032320 positive regulation of Ras GTPase activity
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070371 ERK1 and ERK2 cascade
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0016328 lateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028068
View Gene Order
ENSBTAG00000006882
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591495 Hs.734848
RefSeq NM_178229
HUGO
OMIM
CCDS CCDS1144
HPRD 11051
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca