Version 5.4
Homo sapiens Protein: FCRL5
Summary
InnateDB Protein IDBP-103667.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCRL5
Protein Name Fc receptor-like 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354691
InnateDB Gene IDBG-103665 (FCRL5)
Protein Structure
UniProt Annotation
Function May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. {ECO:0000269PubMed:11453668}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:16849395}.
Disease Associations Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269PubMed:11290337}.
Tissue Specificity Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). {ECO:0000269PubMed:11290337, ECO:0000269PubMed:11929751, ECO:0000269PubMed:16849395}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RD9
PhosphoSite PhosphoSite-Q96RD9
TrEMBL
UniProt Splice Variant
Entrez Gene 83416
UniGene Hs.415950
RefSeq NP_112571
HUGO HGNC:18508
OMIM 605877
CCDS CCDS1165
HPRD 16169
IMGT
EMBL AF343662 AF343663 AF343664 AF343665 AF369794 AF397453 AL135929 AL353899 AL834187 AY358085 BC101066 BC101067 BC101069 EF064730
GenPept AAI01067 AAI01068 AAI01070 AAK31325 AAK31326 AAK31327 AAK31328 AAK50059 AAK93971 AAQ88452 ABK41913 CAH56486 CAH71427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca