Homo sapiens Protein: FCRL5 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-103675.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | FCRL5 | ||||||||||||||||||
Protein Name | Fc receptor-like 5 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000357172 | ||||||||||||||||||
InnateDB Gene | IDBG-103665 (FCRL5) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. {ECO:0000269PubMed:11453668}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:16849395}. | ||||||||||||||||||
Disease Associations | Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269PubMed:11290337}. | ||||||||||||||||||
Tissue Specificity | Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). {ECO:0000269PubMed:11290337, ECO:0000269PubMed:11929751, ECO:0000269PubMed:16849395}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain |
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PFAM | |||||||||||||||||||
PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00408
SM00409 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q96RD9 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q96RD9 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 83416 | ||||||||||||||||||
UniGene | Hs.415950 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:18508 | ||||||||||||||||||
OMIM | 605877 | ||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 16169 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF343662 AF343663 AF343664 AF343665 AF369794 AF397453 AL135929 AL353899 AL834187 AY358085 BC101066 BC101067 BC101069 EF064730 | ||||||||||||||||||
GenPept | AAI01067 AAI01068 AAI01070 AAK31325 AAK31326 AAK31327 AAK31328 AAK50059 AAK93971 AAQ88452 ABK41913 CAH56486 CAH71427 | ||||||||||||||||||