Version 5.4
Homo sapiens Protein: FCRL2
Summary
InnateDB Protein IDBP-103700.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCRL2
Protein Name Fc receptor-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355157
InnateDB Gene IDBG-103696 (FCRL2)
Protein Structure
UniProt Annotation
Function May have an regulatory role in normal and neoplastic B cell development. {ECO:0000269PubMed:11493702}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:16849395}.
Disease Associations
Tissue Specificity Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level). {ECO:0000269PubMed:11162587, ECO:0000269PubMed:11493702, ECO:0000269PubMed:11929751, ECO:0000269PubMed:16849395}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
PFAM PF07679
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LA5
PhosphoSite PhosphoSite-Q96LA5
TrEMBL
UniProt Splice Variant
Entrez Gene 79368
UniGene Hs.437393
RefSeq NP_110391
HUGO HGNC:14875
OMIM 606509
CCDS CCDS1168
HPRD 07351
IMGT
EMBL AF319438 AF319439 AF319440 AF390037 AF459633 AL356276 AY043465 AY358130 BC069185 BC129836 CH471121 EF064733
GenPept AAH69185 AAI29837 AAK01402 AAK01403 AAK01404 AAK91778 AAL60249 AAM12152 AAQ88497 ABK41916 CAH73060 CAH73061 CAH73062 CAH73063 EAW52864 EAW52867 EAW52869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca