Version 5.4
Homo sapiens Gene: FCRL2
Summary
InnateDB Gene IDBG-103696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCRL2
Gene Name Fc receptor-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132704
Encoded Proteins
IDBP-103700
Fc receptor-like 2
IDBP-103702
Fc receptor-like 2
IDBP-476486
Fc receptor-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:157745733-157777132
Strand Reverse strand
Band q23.1
Transcripts
ENST00000361516 ENSP00000355157
ENST00000368181 ENSP00000357163
ENST00000368178
ENST00000469986 ENSP00000417393
ENST00000462774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q96LA5
TrEMBL
UniProt Splice Variant
Entrez Gene 79368
UniGene Hs.437393
RefSeq NM_030764
HUGO HGNC:14875
OMIM 606509
CCDS CCDS1168
HPRD 07351
IMGT
EMBL AF319438 AF319439 AF319440 AF390037 AF459633 AL356276 AY043465 AY358130 BC069185 BC129836 CH471121 EF064733
GenPept AAH69185 AAI29837 AAK01402 AAK01403 AAK01404 AAK91778 AAL60249 AAM12152 AAQ88497 ABK41916 CAH73060 CAH73061 CAH73062 CAH73063 EAW52864 EAW52867 EAW52869
RNA Seq Atlas 79368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca