InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD1D

Summary

InnateDB Protein

IDBP-103735.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD1D

Protein Name

CD1d molecule

Synonyms

CD1A; R3;

Species

Homo sapiens

Ensembl Protein

ENSP00000357153

InnateDB Gene

IDBG-103733 (CD1D)

Protein Structure

UniProt Annotation

Function

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269PubMed:17475845}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.

Disease Associations

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030881	beta-2-microglobulin binding
GO:0030882	lipid antigen binding
GO:0030884	exogenous lipid antigen binding
GO:0042393	histone binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0016032	viral process
GO:0016045	detection of bacterium
GO:0034113	heterotypic cell-cell adhesion
GO:0042102	positive regulation of T cell proliferation
GO:0045058	T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib