InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD1D

Summary

InnateDB Gene

IDBG-103733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD1D

Gene Name

CD1d molecule

Synonyms

CD1A; R3

Species

Homo sapiens

Ensembl Gene

ENSG00000158473

Encoded Proteins

IDBP-103735

CD1d molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24248359

Lipid transfer proteins saposins play an essential role in modulating human invariant natural killer T cell reactivity to antigen-presenting cells activated by inflammatory stimuli. Lipid-loaded Saposin B mediates lipid transfer onto CD1D and accelerates dissociation of CD1D-bound lipids, promoting lipid exchange.

Entrez Gene

Summary

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:158179947-158184896

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000368171

ENSP00000357153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030881	beta-2-microglobulin binding
GO:0030882	lipid antigen binding
GO:0030884	exogenous lipid antigen binding
GO:0042393	histone binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0016032	viral process
GO:0016045	detection of bacterium
GO:0034113	heterotypic cell-cell adhesion
GO:0042102	positive regulation of T cell proliferation
GO:0045058	T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000028076

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa05146

Amoebiasis pathway

INOH

PID NCI

Cross-References

SwissProt

P15813

TrEMBL

UniProt Splice Variant

Entrez Gene

912

UniGene

Hs.1799 Hs.605289

RefSeq

NM_001766 XM_006711621

HUGO

HGNC:1637

OMIM

188410

CCDS

CCDS1173

HPRD

IMGT

EMBL

AF142668 AL138899 BC027926 CH471121 J04142 L38815 L38816 L38817 L38818 L38819 L38820 M14664 X14974

GenPept

AAA51935 AAA59672 AAA59673 AAD37581 AAH27926 CAA33099 CAH73515 EAW52847 EAW52848 EAW52849

RNA Seq Atlas

912