InnateDB Protein
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IDBP-103843.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PYHIN1
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Protein Name
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pyrin and HIN domain family, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357122
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InnateDB Gene
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IDBG-103841 (PYHIN1)
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Protein Structure
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Function |
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269PubMed:16479015, ECO:0000269PubMed:18247378}.
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Subcellular Localization |
Isoform 1: Nucleus, nucleoplasm.Isoform 3: Nucleus, nucleoplasm.Isoform 5: Nucleus. Nucleus speckle.
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Disease Associations |
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Tissue Specificity |
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269PubMed:15122330}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004020
DAPIN domain
IPR004021
HIN-200/IF120x
IPR011029
Death-like domain
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PFAM |
PF02758
PF02760
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6K0P9
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PhosphoSite |
PhosphoSite-Q6K0P9
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TrEMBL |
X6RHR0
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UniProt Splice Variant |
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Entrez Gene |
149628
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UniGene |
Hs.734876
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RefSeq |
NP_689714
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HUGO |
HGNC:28894
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OMIM |
612677
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CCDS |
CCDS1178
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HPRD |
09999
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IMGT |
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EMBL |
AL359753
AY185344
AY185345
AY185346
AY185347
BC020822
BC090944
BC139741
CH471121
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GenPept |
AAH20822
AAH90944
AAI39742
AAO67506
AAO67507
AAO67508
AAO67509
CAI15075
CAI15076
CAI15077
CAI15078
CAI15079
CAI15080
EAW52805
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