Version 5.4
Homo sapiens Protein: CADM3
Summary
InnateDB Protein IDBP-103870.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CADM3
Protein Name cell adhesion molecule 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357107
InnateDB Gene IDBG-103868 (CADM3)
Protein Structure
UniProt Annotation
Function Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at the cell-cell attached sites of the plasma membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. {ECO:0000269PubMed:11536053, ECO:0000269PubMed:15893517, ECO:0000269PubMed:18420026}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003585 Neurexin/syndecan/glycophorin C
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF07654
PF07679
PF07686
PF00047
PF08205
PRINTS
PIRSF
SMART SM00294
SM00407
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N126
PhosphoSite PhosphoSite-Q8N126
TrEMBL
UniProt Splice Variant
Entrez Gene 57863
UniGene Hs.365689
RefSeq NP_001120645
HUGO HGNC:17601
OMIM 609743
CCDS CCDS44251
HPRD 13733
IMGT
EMBL AF062733 AF363367 AF529206 AK001560 AL035403 AY046418 AY358332
GenPept AAD17540 AAL02143 AAM60749 AAN75603 AAQ88698 BAA91756 CAB56227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca