InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APCS

Summary

InnateDB Protein

IDBP-103907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APCS

Protein Name

amyloid P component, serum

Synonyms

HEL-S-92n; PTX2; SAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000255040

InnateDB Gene

IDBG-103905 (APCS)

Protein Structure

UniProt Annotation

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Subcellular Localization

Secreted.

Disease Associations

Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Tissue Specificity

Found in serum and urine. {ECO:0000269PubMed:15174148}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0005509	calcium ion binding
GO:0046790	virion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0002674	negative regulation of acute inflammatory response
GO:0006457	protein folding
GO:0006461	protein complex assembly
GO:0006953	acute-phase response
GO:0045087	innate immune response (InnateDB)
GO:0045656	negative regulation of monocyte differentiation
GO:0046597	negative regulation of viral entry into host cell
GO:0048525	negative regulation of viral process
GO:0051131	chaperone-mediated protein complex assembly
GO:0061045	negative regulation of wound healing
GO:1903016	negative regulation of exo-alpha-sialidase activity
GO:1903019	negative regulation of glycoprotein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle