Version 5.4
Homo sapiens Gene: APCS
Summary
InnateDB Gene IDBG-103905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APCS
Gene Name amyloid P component, serum
Synonyms HEL-S-92n; PTX2; SAP
Species Homo sapiens
Ensembl Gene ENSG00000132703
Encoded Proteins
IDBP-103907
amyloid P component, serum
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21278351
APCS is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. APCS-DNA complex showed significant defects in innate immune activation, and specifically inhibits the functions of HMGB1 and antimicrobial peptide LL37.
InnateDB Annotation from Orthologs
Summary
PMID 21278351
[Mus musculus] Apcs is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. Murine Apcs exhibited a similar, albeit very weak, activity.
Entrez Gene
Summary The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:159587825-159588865
Strand Forward strand
Band q23.2
Transcripts
ENST00000255040 ENSP00000255040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 20 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0005509 calcium ion binding
GO:0046790 virion binding
GO:0051082 unfolded protein binding
Biological Process
GO:0002674 negative regulation of acute inflammatory response
GO:0006457 protein folding
GO:0006461 protein complex assembly
GO:0006953 acute-phase response
GO:0045087 innate immune response (InnateDB)
GO:0045656 negative regulation of monocyte differentiation
GO:0046597 negative regulation of viral entry into host cell
GO:0048525 negative regulation of viral process
GO:0051131 chaperone-mediated protein complex assembly
GO:0061045 negative regulation of wound healing
GO:1903016 negative regulation of exo-alpha-sialidase activity
GO:1903019 negative regulation of glycoprotein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0031012 extracellular matrix
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026542
View Gene Order
ENSBTAG00000019616
Not yet available
Pathways
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P02743
TrEMBL V9HWP0
UniProt Splice Variant
Entrez Gene 325
UniGene
RefSeq NM_001639
HUGO HGNC:584
OMIM 104770
CCDS CCDS1186
HPRD
IMGT
EMBL AL445528 BC007039 BC007058 BT006750 CH471121 CR450313 D00097 FJ460512 M10944 X04608
GenPept AAA60302 AAH07039 AAH07058 AAP35396 ACS44649 BAA00060 CAA28275 CAG29309 CAH73651 EAW52781
RNA Seq Atlas 325

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca