InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1A2

Summary

InnateDB Protein

IDBP-103995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A2

Protein Name

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Synonyms

FHM2; MHP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000354490

InnateDB Gene

IDBG-103993 (ATP1A2)

Protein Structure

UniProt Annotation

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.

Subcellular Localization

Membrane {ECO:0000269PubMed:7711835}; Multi-pass membrane protein {ECO:0000269PubMed:7711835}. Cell membrane {ECO:0000269PubMed:7711835}; Multi-pass membrane protein {ECO:0000269PubMed:7711835}.

Disease Associations

Migraine, familial hemiplegic, 2 (FHM2) [MIM:602481]: A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO:0000269PubMed:12539047, ECO:0000269PubMed:12953268, ECO:0000269PubMed:21352219, ECO:0000269PubMed:23838748, ECO:0000269PubMed:23918834}. Note=The disease is caused by mutations affecting the gene represented in this entry.Alternating hemiplegia of childhood 1 (AHC1) [MIM:104290]: A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age. {ECO:0000269PubMed:15174025}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0001504	neurotransmitter uptake
GO:0002026	regulation of the force of heart contraction
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0006942	regulation of striated muscle contraction
GO:0008217	regulation of blood pressure
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0019229	regulation of vasoconstriction
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035725	sodium ion transmembrane transport
GO:0040011	locomotion
GO:0045822	negative regulation of heart contraction
GO:0045988	negative regulation of striated muscle contraction
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055085	transmembrane transport
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt