InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1A4

Summary

InnateDB Protein

IDBP-104000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A4

Protein Name

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Synonyms

ATP1A1; ATP1AL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000357060

InnateDB Gene

IDBG-103998 (ATP1A4)

Protein Structure

UniProt Annotation

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16175638}; Multi-pass membrane protein {ECO:0000269PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum.

Disease Associations

Tissue Specificity

Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0030317	sperm motility
GO:0030641	regulation of cellular pH
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt