Version 5.4
Homo sapiens Protein: SLAMF6
Summary
InnateDB Protein IDBP-104059.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLAMF6
Protein Name SLAM family member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357034
InnateDB Gene IDBG-104051 (SLAMF6)
Protein Structure
UniProt Annotation
Function Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. {ECO:0000269PubMed:11489943}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. {ECO:0000269PubMed:11489943}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DU3
PhosphoSite PhosphoSite-Q96DU3
TrEMBL
UniProt Splice Variant
Entrez Gene 114836
UniGene Hs.492348
RefSeq NP_001171645
HUGO HGNC:21392
OMIM 606446
CCDS CCDS53393
HPRD 05920
IMGT
EMBL AJ277141 AJ306388 AK125624 AK301026 AK313549 AL138930 AL832854 AY358159 BC113893 BC114495 CH471121
GenPept AAI13894 AAI14496 AAQ88526 BAG36325 BAG54223 BAG62642 CAC59749 CAC59750 CAI15155 CAI15156 CAI15157 CAI46161 EAW52713 EAW52715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca