InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IMPA2

Summary

InnateDB Protein

IDBP-1041.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPA2

Protein Name

inositol(myo)-1(or 4)-monophosphatase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269159

InnateDB Gene

IDBG-1039 (IMPA2)

Protein Structure

UniProt Annotation

Function

Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. {ECO:0000269PubMed:17068342}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008934	inositol monophosphate 1-phosphatase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0052832	inositol monophosphate 3-phosphatase activity
GO:0052833	inositol monophosphate 4-phosphatase activity

Biological Process

GO:0006021	inositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0007165	signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0046855	inositol phosphate dephosphorylation