Version 5.4
Homo sapiens Gene: IMPA2
Summary
InnateDB Gene IDBG-1039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPA2
Gene Name inositol(myo)-1(or 4)-monophosphatase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141401
Encoded Proteins
IDBP-1041
inositol(myo)-1(or 4)-monophosphatase 2
IDBP-1043
inositol(myo)-1(or 4)-monophosphatase 2
IDBP-725533
IDBP-727864
IDBP-726362
IDBP-727209
IDBP-726574
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:11981025-12030883
Strand Forward strand
Band p11.21
Transcripts
ENST00000269159 ENSP00000269159
ENST00000383376 ENSP00000372867
ENST00000590107 ENSP00000466059
ENST00000588167
ENST00000588752
ENST00000588863
ENST00000586230 ENSP00000464754
ENST00000590138 ENSP00000465938
ENST00000589374
ENST00000588927 ENSP00000464767
ENST00000589238 ENSP00000465416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008934 inositol monophosphate 1-phosphatase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052832 inositol monophosphate 3-phosphatase activity
GO:0052833 inositol monophosphate 4-phosphatase activity
Biological Process
GO:0006021 inositol biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0007165 signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0046855 inositol phosphate dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024525
View Gene Order
ENSBTAG00000043951
Not yet available
Pathways
NETPATH
REACTOME
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL K7EII9
UniProt Splice Variant
Entrez Gene 3613
UniGene
RefSeq NM_014214
HUGO HGNC:6051
OMIM 605922
CCDS CCDS11855
HPRD 09329
IMGT
EMBL AP001269 AP001542
GenPept
RNA Seq Atlas 3613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca