InnateDB Protein
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IDBP-104183.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NIT1
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Protein Name
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nitrilase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356988
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InnateDB Gene
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IDBG-104181 (NIT1)
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Protein Structure
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Function |
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9671749}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000257
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nitrilase activity
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GO:0016810
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003010
Carbon-nitrogen hydrolase
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PFAM |
PF00795
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86X76
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PhosphoSite |
PhosphoSite-Q86X76
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4817
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UniGene |
Hs.741277
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RefSeq |
NP_005591
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HUGO |
HGNC:7828
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OMIM |
604618
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CCDS |
CCDS1218
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HPRD |
07056
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IMGT |
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EMBL |
AF069984
AF069987
AL591806
BC046149
CH471121
CR541814
CR541846
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GenPept |
AAC39901
AAC39907
AAH46149
CAG46613
CAG46644
CAI15379
EAW52654
EAW52656
EAW52657
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