Version 5.4
Homo sapiens Gene: NIT1
Summary
InnateDB Gene IDBG-104181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NIT1
Gene Name nitrilase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158793
Encoded Proteins
IDBP-104183
nitrilase 1
IDBP-104185
nitrilase 1
IDBP-104187
nitrilase 1
IDBP-246163
nitrilase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161118086-161125445
Strand Forward strand
Band q23.3
Transcripts
ENST00000368009 ENSP00000356988
ENST00000368008 ENSP00000356987
ENST00000368007 ENSP00000356986
ENST00000392190 ENSP00000376028
ENST00000496768
ENST00000479266
ENST00000477684
ENST00000486962
ENST00000492411
ENST00000473918
ENST00000478277
ENST00000496861
ENST00000491497
ENST00000485594
ENST00000461376
ENST00000479728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000257 nitrilase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013997
View Gene Order
ENSBTAG00000020153
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741277
RefSeq NM_001185092 NM_001185093 NM_001185094 NM_005600 XM_005245214 XM_005245215 XM_005245216
HUGO
OMIM
CCDS CCDS1218 CCDS53401 CCDS53402 CCDS53403
HPRD 07056
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca