Version 5.4
Homo sapiens Protein: NIT1
Summary
InnateDB Protein IDBP-104187.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NIT1
Protein Name nitrilase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356986
InnateDB Gene IDBG-104181 (NIT1)
Protein Structure
UniProt Annotation
Function Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9671749}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000257 nitrilase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003010 Carbon-nitrogen hydrolase
PFAM PF00795
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86X76
PhosphoSite PhosphoSite-Q86X76
TrEMBL
UniProt Splice Variant
Entrez Gene 4817
UniGene Hs.741277
RefSeq NP_001172022
HUGO HGNC:7828
OMIM 604618
CCDS CCDS53402
HPRD 07056
IMGT
EMBL AF069984 AF069987 AL591806 BC046149 CH471121 CR541814 CR541846
GenPept AAC39901 AAC39907 AAH46149 CAG46613 CAG46644 CAI15379 EAW52654 EAW52656 EAW52657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca