InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEDD

Summary

InnateDB Protein

IDBP-104190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEDD

Protein Name

death effector domain containing

Synonyms

CASP8IP1; DEDD1; DEFT; FLDED1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356985

InnateDB Gene

IDBG-104188 (DEDD)

Protein Structure

UniProt Annotation

Function

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in testis. {ECO:0000269PubMed:9832420}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0042177	negative regulation of protein catabolic process
GO:0042981	regulation of apoptotic process
GO:0046697	decidualization
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter