Version 5.4
Homo sapiens Protein: USP21
Summary
InnateDB Protein IDBP-104198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP21
Protein Name ubiquitin specific peptidase 21
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356981
InnateDB Gene IDBG-104196 (USP21)
Protein Structure
UniProt Annotation
Function Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. {ECO:0000250, ECO:0000269PubMed:10799498}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21888622}. Nucleus {ECO:0000269PubMed:21888622}.
Disease Associations
Tissue Specificity Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung. {ECO:0000269PubMed:10799498}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0019784 NEDD8-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016578 histone deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UK80
PhosphoSite PhosphoSite-Q9UK80
TrEMBL V9GYJ6
UniProt Splice Variant
Entrez Gene 27005
UniGene Hs.8015
RefSeq NP_001014443
HUGO HGNC:12620
OMIM 604729
CCDS CCDS30920
HPRD 05291
IMGT
EMBL AB208899 AF177758 AF217979 AF233442 AK292319 AL590714 BC003130 BC090946 BC136291 CH471121
GenPept AAD54321 AAF61308 AAG17222 AAH03130 AAH90946 AAI36292 BAD92136 BAF85008 CAH72142 CAH72143 EAW52644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca