Version 5.4
Homo sapiens Gene: USP21
Summary
InnateDB Gene IDBG-104196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP21
Gene Name ubiquitin specific peptidase 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143258
Encoded Proteins
IDBP-104198
ubiquitin specific peptidase 21
IDBP-104202
ubiquitin specific peptidase 21
IDBP-104204
ubiquitin specific peptidase 21
IDBP-812019
ubiquitin specific peptidase 21
IDBP-812029
ubiquitin specific peptidase 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161159450-161165723
Strand Forward strand
Band q23.3
Transcripts
ENST00000368002 ENSP00000356981
ENST00000289865 ENSP00000289865
ENST00000368001 ENSP00000356980
ENST00000492950 ENSP00000476344
ENST00000479344 ENSP00000476830
ENST00000486299
ENST00000487163
ENST00000482385
ENST00000493054
ENST00000485277
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0019784 NEDD8-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016578 histone deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053483
View Gene Order
ENSBTAG00000021893
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.8015
RefSeq NM_001014443 NM_012475 XM_006711273
HUGO
OMIM
CCDS CCDS30920
HPRD 05291
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca