Version 5.4
Homo sapiens Protein: FCGR2A
Summary
InnateDB Protein IDBP-104286.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR2A
Protein Name Fc fragment of IgG, low affinity IIa, receptor (CD32)
Synonyms CD32; CD32A; CDw32; FCG2; FcGR; FCGR2; FCGR2A1; IGFR2;
Species Homo sapiens
Ensembl Protein ENSP00000356949
InnateDB Gene IDBG-104282 (FCGR2A)
Protein Structure
UniProt Annotation
Function Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269PubMed:19011614}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269PubMed:19011614}.
Disease Associations
Tissue Specificity Found on monocytes, neutrophils and eosinophil platelets.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12318
PhosphoSite PhosphoSite-P12318
TrEMBL
UniProt Splice Variant
Entrez Gene 9103
UniGene Hs.717076
RefSeq NP_067674
HUGO HGNC:3616
OMIM 612169
CCDS CCDS30922
HPRD 00906
IMGT
EMBL AL590385 BC019931 BC020823 J03619 M31932 Y00644
GenPept AAA35827 AAA35932 AAH19931 AAH20823 CAA68672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca