InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGR3A

Summary

InnateDB Protein

IDBP-104296.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR3A

Protein Name

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Synonyms

CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20;

Species

Homo sapiens

Ensembl Protein

ENSP00000356944

InnateDB Gene

IDBG-104292 (FCGR3A)

Protein Structure

UniProt Annotation

Function

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. {ECO:0000269PubMed:21768335, ECO:0000269PubMed:22023369}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Exists also as a soluble receptor.

Disease Associations

Tissue Specificity

Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0006955	immune response
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0050776	regulation of immune response