InnateDB Protein
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IDBP-104318.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCGR2B
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Protein Name
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Fc fragment of IgG, low affinity IIb, receptor (CD32)
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Synonyms
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CD32; CD32B; FCG2; FCGR2; IGFR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000236937
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InnateDB Gene
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IDBG-104308 (FCGR2B)
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Protein Structure
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Function |
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:12115230, ECO:0000269PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003598
Immunoglobulin subtype 2
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00408
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
P31994
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PhosphoSite |
PhosphoSite-P31994
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TrEMBL |
Q8NIA0
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UniProt Splice Variant |
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Entrez Gene |
2213
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UniGene |
Hs.666187
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RefSeq |
NP_001002274
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HUGO |
HGNC:3618
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OMIM |
604590
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CCDS |
CCDS30925
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HPRD |
06849
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IMGT |
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EMBL |
AB050934
AB051387
AB060143
AB060147
AB060149
AB060150
AB062416
AF433951
AL359541
BC031992
BC146678
CR407635
M31933
M31934
M31935
U87560
U87561
U87562
U87563
U87564
U87565
U87566
U87567
U87568
U87569
U87570
U87571
U87572
U87573
U87574
U87575
U87576
U87577
X17653
X52473
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GenPept |
AAA35841
AAA35842
AAA35843
AAD00627
AAD00628
AAD00629
AAD00630
AAD00631
AAD00632
AAD00633
AAD00634
AAD00635
AAD00636
AAD00637
AAD00638
AAD00639
AAD00640
AAD00641
AAD00642
AAD00643
AAD00644
AAH31992
AAI46679
AAN14522
BAB92093
BAB92094
BAB92095
BAC54013
BAC54017
BAC54019
BAC54020
CAA35644
CAA35645
CAA36713
CAG28563
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