Version 5.4
| Homo sapiens Gene: FCGR2B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-104308.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FCGR2B | ||||||||||||||||||
| Gene Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) | ||||||||||||||||||
| Synonyms | CD32; CD32B; FCG2; FCGR2; IGFR2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000072694 | ||||||||||||||||||
| Encoded Proteins |
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:161581311-161678654 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q23.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
BCR pathway
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| REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
B cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Staphylococcus aureus infection pathway
Osteoclast differentiation pathway
Phagosome pathway
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| INOH | |||||||||||||||||||
| PID NCI |
BCR signaling pathway
Fc-epsilon receptor I signaling in mast cells
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.654395 Hs.666187 | ||||||||||||||||||
| RefSeq | NM_001002273 NM_001002274 NM_001002275 NM_001190828 NM_004001 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS30924 CCDS30925 CCDS53414 | ||||||||||||||||||
| HPRD | 06849 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||