InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP12

Summary

InnateDB Protein

IDBP-104357.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP12

Protein Name

dual specificity phosphatase 12

Synonyms

DUSP1; YVH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356920

InnateDB Gene

IDBG-104355 (DUSP12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008270	zinc ion binding
GO:0016791	phosphatase activity
GO:0019900	kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0033133	positive regulation of glucokinase activity
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR007087 Zinc finger, C2H2
IPR016278 Dual specificity protein phosphatase 12
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF00096

PRINTS

PIRSF

PIRSF000941

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt