Version 5.4
Homo sapiens Gene: DUSP12
Summary
InnateDB Gene IDBG-104355.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP12
Gene Name dual specificity phosphatase 12
Synonyms DUSP1; YVH1
Species Homo sapiens
Ensembl Gene ENSG00000081721
Encoded Proteins
IDBP-104357
dual specificity phosphatase 12
IDBP-808228
dual specificity phosphatase 12
IDBP-808246
dual specificity phosphatase 12
IDBP-808250
dual specificity phosphatase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161749758-161757238
Strand Forward strand
Band q23.3
Transcripts
ENST00000367943 ENSP00000356920
ENST00000484291 ENSP00000476528
ENST00000464004 ENSP00000476912
ENST00000490591 ENSP00000477122
ENST00000463365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008270 zinc ion binding
GO:0016791 phosphatase activity
GO:0019900 kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0033133 positive regulation of glucokinase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026659
View Gene Order
ENSBTAG00000021754
Not yet available
Cross-References
SwissProt Q9UNI6
TrEMBL V9GY92 V9GYV5
UniProt Splice Variant
Entrez Gene 11266
UniGene Hs.416216
RefSeq NM_007240 XM_005244862
HUGO HGNC:3067
OMIM 604835
CCDS CCDS1234
HPRD
IMGT
EMBL AF119226 AL359541 BC006286 BT006633
GenPept AAD51134 AAH06286 AAP35279 CAH74153
RNA Seq Atlas 11266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca