InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOS1AP

Summary

InnateDB Protein

IDBP-104370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS1AP

Protein Name

nitric oxide synthase 1 (neuronal) adaptor protein

Synonyms

6330408P19Rik; CAPON;

Species

Homo sapiens

Ensembl Protein

ENSP00000355133

InnateDB Gene

IDBG-104368 (NOS1AP)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0042981	regulation of apoptotic process
GO:0045428	regulation of nitric oxide biosynthetic process
GO:0050999	regulation of nitric-oxide synthase activity