Version 5.4
Homo sapiens Gene: NOS1AP
Summary
InnateDB Gene IDBG-104368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOS1AP
Gene Name nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms 6330408P19Rik; CAPON
Species Homo sapiens
Ensembl Gene ENSG00000198929
Encoded Proteins
IDBP-104370
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-104378
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-389420
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-598636
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-599322
nitric oxide synthase 1 (neuronal) adaptor protein
IDBP-596472
nitric oxide synthase 1 (neuronal) adaptor protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:162069774-162370475
Strand Forward strand
Band q23.3
Transcripts
ENST00000361897 ENSP00000355133
ENST00000367932 ENSP00000356909
ENST00000430120 ENSP00000396713
ENST00000454693
ENST00000464284 ENSP00000435711
ENST00000493151 ENSP00000434988
ENST00000530878 ENSP00000431586
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0042981 regulation of apoptotic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0050999 regulation of nitric-oxide synthase activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038473
View Gene Order
ENSBTAG00000010158
Not yet available
Cross-References
SwissProt
TrEMBL E9PIP8
UniProt Splice Variant
Entrez Gene 9722
UniGene Hs.655000 Hs.731942
RefSeq NM_001126060 NM_001164757 NM_014697
HUGO HGNC:16859
OMIM 605551
CCDS CCDS1237 CCDS44267 CCDS53421
HPRD 12023
IMGT
EMBL AL450163 AL512785 AL590408
GenPept
RNA Seq Atlas 9722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca