InnateDB Protein
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IDBP-104389.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UAP1
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Protein Name
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UDP-N-acteylglucosamine pyrophosphorylase 1
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Synonyms
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AGX; AGX1; AGX2; SPAG2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356903
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InnateDB Gene
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IDBG-104387 (UAP1)
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Protein Structure
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Function |
Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
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Subcellular Localization |
Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006047
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UDP-N-acetylglucosamine metabolic process
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GO:0006048
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UDP-N-acetylglucosamine biosynthetic process
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GO:0006488
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dolichol-linked oligosaccharide biosynthetic process
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GO:0008152
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metabolic process
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GO:0018279
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protein N-linked glycosylation via asparagine
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GO:0043687
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post-translational protein modification
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GO:0044267
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cellular protein metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR002618
UTP--glucose-1-phosphate uridylyltransferase family
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF01704
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16222
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PhosphoSite |
PhosphoSite-Q16222
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6675
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UniGene |
Hs.598015
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RefSeq |
NP_003106
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HUGO |
HGNC:12457
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OMIM |
602862
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CCDS |
CCDS1240
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HPRD |
04178
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IMGT |
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EMBL |
AB011004
AK312685
AL596325
BC009377
CH471067
S73498
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GenPept |
AAB31210
AAH09377
BAA31202
BAG35565
CAH72978
CAH72979
CAH72980
EAW90710
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