InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UAP1

Summary

InnateDB Protein

IDBP-104391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UAP1

Protein Name

UDP-N-acteylglucosamine pyrophosphorylase 1

Synonyms

AGX; AGX1; AGX2; SPAG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000271469

InnateDB Gene

IDBG-104387 (UAP1)

Protein Structure

UniProt Annotation

Function

Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Subcellular Localization

Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.

Disease Associations

Tissue Specificity

Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity
GO:0070569	uridylyltransferase activity

Biological Process

GO:0006048	UDP-N-acetylglucosamine biosynthetic process
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0008152	metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process