InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD17B7

Summary

InnateDB Protein

IDBP-104406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B7

Protein Name

hydroxysteroid (17-beta) dehydrogenase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254521

InnateDB Gene

IDBG-104404 (HSD17B7)

Protein Structure

UniProt Annotation

Function

Responsible for the reduction of the keto group on the C-3 of sterols. {ECO:0000269PubMed:12829805}.

Subcellular Localization

Cell membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000253	3-keto sterol reductase activity
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005148	prolactin receptor binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process