InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RXRG

Summary

InnateDB Protein

IDBP-104465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXRG

Protein Name

retinoid X receptor, gamma

Synonyms

NR2B3; RXRC;

Species

Homo sapiens

Ensembl Protein

ENSP00000352900

InnateDB Gene

IDBG-104461 (RXRG)

Protein Structure

UniProt Annotation

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0010467	gene expression
GO:0014070	response to organic cyclic compound
GO:0030182	neuron differentiation
GO:0031641	regulation of myelination
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021780 Nuclear/hormone receptor activator site AF-1

PFAM

PF00104
PF00105
PF11825

PRINTS

PR00545
PR00047
PR00398
PR01282

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt