InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR161

Summary

InnateDB Protein

IDBP-104598.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR161

Protein Name

G protein-coupled receptor 161

Synonyms

RE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356812

InnateDB Gene

IDBG-104596 (GPR161)

Protein Structure

UniProt Annotation

Function

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning