Version 5.4
Homo sapiens Protein: TIPRL
Summary
InnateDB Protein IDBP-104609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIPRL
Protein Name TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356807
InnateDB Gene IDBG-104607 (TIPRL)
Protein Structure
UniProt Annotation
Function May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269PubMed:17384681}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17944932}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0034048 negative regulation of protein phosphatase type 2A activity
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR007303 TIP41-like protein
PFAM PF04176
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75663
PhosphoSite PhosphoSite-O75663
TrEMBL
UniProt Splice Variant
Entrez Gene 261726
UniGene
RefSeq NP_690866
HUGO HGNC:30231
OMIM 611807
CCDS CCDS1270
HPRD 14608
IMGT
EMBL AB097034 AK313520 AL021397 AL049670 BC009506 BX648646 CH471067
GenPept AAH09506 BAC77387 BAG36300 CAA16171 CAB41244 CAI22473 CAI46265 EAW90821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca