Version 5.4
Homo sapiens Gene: TIPRL
Summary
InnateDB Gene IDBG-104607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIPRL
Gene Name TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143155
Encoded Proteins
IDBP-104609
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
IDBP-104613
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:168178933-168202114
Strand Forward strand
Band q24.2
Transcripts
ENST00000367833 ENSP00000356807
ENST00000367830 ENSP00000356804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0034048 negative regulation of protein phosphatase type 2A activity
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040843
View Gene Order
ENSBTAG00000005393
Not yet available
Cross-References
SwissProt O75663
TrEMBL
UniProt Splice Variant
Entrez Gene 261726
UniGene
RefSeq NM_152902 NM_001031800
HUGO HGNC:30231
OMIM 611807
CCDS CCDS1270 CCDS30935
HPRD 14608
IMGT
EMBL AB097034 AK313520 AL021397 AL049670 BC009506 BX648646 CH471067
GenPept AAH09506 BAC77387 BAG36300 CAA16171 CAB41244 CAI22473 CAI46265 EAW90821
RNA Seq Atlas 261726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca