InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1B1

Summary

InnateDB Protein

IDBP-104643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1B1

Protein Name

ATPase, Na+/K+ transporting, beta 1 polypeptide

Synonyms

ATP1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000356789

InnateDB Gene

IDBG-104639 (ATP1B1)

Protein Structure

UniProt Annotation

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO:0000269PubMed:19694409}.Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269PubMed:19694409}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Found in most tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0006810	transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport