Version 5.4
Homo sapiens Gene: ATP1B1
Summary
InnateDB Gene IDBG-104639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1B1
Gene Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms ATP1B
Species Homo sapiens
Ensembl Gene ENSG00000143153
Encoded Proteins
IDBP-104641
ATPase, Na+/K+ transporting, beta 1 polypeptide
IDBP-104643
ATPase, Na+/K+ transporting, beta 1 polypeptide
IDBP-812988
ATPase, Na+/K+ transporting, beta 1 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169105697-169132722
Strand Forward strand
Band q24.2
Transcripts
ENST00000367816 ENSP00000356790
ENST00000367815 ENSP00000356789
ENST00000494797 ENSP00000477015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0001666 response to hypoxia
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0030001 metal ion transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026576
View Gene Order
ENSBTAG00000002688
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt P05026
TrEMBL A3KLL5 B7Z9S8 Q58I20 V9GYR2
UniProt Splice Variant
Entrez Gene 481
UniGene Hs.291196 Hs.733038
RefSeq NM_001677
HUGO HGNC:804
OMIM 182330
CCDS CCDS1276
HPRD 01663
IMGT
EMBL AK290181 AK316043 AL031726 AY545986 AY946016 BC000006 BT009787 CH471067 M25160 M25161 U16799 X03747 X17161
GenPept AAA36352 AAC50132 AAH00006 AAP88789 AAT11781 AAX55911 BAF82870 BAH14414 CAA27385 CAA35040 CAI18888 EAW90832
RNA Seq Atlas 481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca