InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCYL3

Summary

InnateDB Protein

IDBP-104727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCYL3

Protein Name

SCY1-like 3 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356746

InnateDB Gene

IDBG-104732 (SCYL3)

Protein Structure

UniProt Annotation

Function

May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269PubMed:12651155}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12651155}. Golgi apparatus {ECO:0000269PubMed:12651155}. Cell projection, lamellipodium {ECO:0000269PubMed:12651155}. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12651155}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0016477	cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt